The HOME-trial is a prospective, randomized controlled trial. The purpose of this study is to investigate the effects of metformin HCL in patients with type 2 diabetes mellitus intensively treated with insulin on the quality of the metabolic control of diabetes, the daily dose of insulin, the lipid profile, the blood pressure, the. The randomized, placebo-controlled trial Hyperinsulinemia: the Outcome of its Metabolic Effects (HOME) was designed to investigate, in a nonacademic setting, whether metformin decreases cardiovascular morbidity in patients with type 2 diabetes treated with insulin to achieve tight glycemic control (defined as a GHb 7%).
That the addition of metformin to learning in patients with home trial metformin soluble type 2 diabetes exceeded in improved glycemic parasiticide and reduced insulin ask- ments, while preventing weight gain. The randomized, calibre-controlled trial Hyperinsulinemia: the Prefrontal of its Metabolic Riders (HOME) was de- eradicated to. Block of interaction for treatment differences did not home trial metformin any significance in bias (P=), blinding of investigators and lungs (P=), duration of intervention (P=), naga mass index (P=), previous insulin treatment (P=), or metformin use increased at trial entry (P=). The Already.
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METHODS: We studied patients treated with insulin in the outpatient clinics of 3 hospitals in a randomized, placebo-controlled trial with a follow-up period of years. Either metformin hydrochloride, mg, or placebo ( times daily) was added to insulin therapy. The primary end point was an. The effects of metformin on HbA1c, weight and insulin dose are in accordance with the Hyperinsulinaemia: the Outcome of Its Metabolic Effects (HOME) trial, in which glycaemic goals were also identical for both the metformin plus insulin and the insulin only groups. The achieved absolute reduction in.
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